Mullerian inhibiting substance type II receptor as a potential target for antineoplastic therapy
نویسندگان
چکیده
منابع مشابه
Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance.
Mullerian Inhibiting Substance (MIS), a 140-kDa homodimer glycoprotein member of the TGF-beta superfamily of biological-response modifiers, causes regression of the Mullerian ducts in developing male embryos. MIS also can induce growth arrest and apoptosis in ovarian and cervical cancer cell lines. The embryonic progenitor of the ovarian and cervical epithelium is the coelomic epithelium, the s...
متن کاملMullerian inhibiting substance: a gonadal hormone with multiple functions.
Mullerian inhibiting substance (MIS) is the gonadal hormone that causes regression of the Mullerian ducts, the anlagen of the female internal reproductive structures, during male embryogenesis. MIS is a member of the large transforming growth factor-beta (TGF beta) multigene family of glycoproteins that are involved in the regulation of growth and differentiation. The proteins in this gene fami...
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متن کاملRegulation of gonadotropin gene expression by Mullerian inhibiting substance.
In addition to its role in causing Müllerian duct regression, Müllerian inhibiting substance (MIS) is implicated in the regulation of steroidogenesis, breast and prostate growth, and ovarian follicle recruitment, all of which are processes controlled or influenced by the hypothalamic-pituitary-gonadal axis. Whereas the direct effect of MIS on gonadal, prostate, and breast cells is under investi...
متن کاملAn update on Mullerian-inhibiting substance: its potential application against ovarian cancer.
Each year, ∼25 000 women are newly diagnosed with ovarian cancer in the USA. The vast majority (>90%) of cases are of epithelial origin. This highly lethal cancer carries a mortality rate of >50% and a high risk of recurrence after conventional, first-line chemotherapy. Müllerian-inhibiting substance (MIS) is a gonadal hormone that causes regression of the Müllerian ducts. A series of studies h...
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ژورنال
عنوان ژورنال: Biomeditsinskaya Khimiya
سال: 2019
ISSN: 2310-6905,2310-6972
DOI: 10.18097/pbmc20196503202